PDB(complex)   |  PDB(Receptor Apo)   |  PDB(Ligand) or mol2

PDBcal ID: 213
Receptor Name: acteylhexosaminyltransferase
Receptor Type: transferase
Ligand Name: UDP-GalNAc
Ligand Type: sugar
PDB Complex: 1OMZ
PDB Receptor: 1OMX
PDB Ligand:
Coordinate Comments:
Receptor: Human alpha -1,4-N acteylhexosaminyltransferase (EXTL2);
EXTL2: exostosin-like protein 2 ;
Since N-terminal donor binding
subdomain nearly identical in all of the structures of glycosyltransferases, the crystal structure is mouse EXTL2 while the thermodynamic date are based on human EXTL2.

pH: 7.5
Temperature: 303
ΔG(kcal/mol): -5.84±0.07
ΔH(kcal/mol): -2.1±0.07
TΔS(kcal/mol): 3.74
ΔCp(cal/molT):
Proton Transfer:
# of Protons:
Stoichiometry: 0.968
Thermodynamics Comments:




Journal: THE JOURNAL OF BIOLOGICAL CHEMISTRY
Pub. Title: Two-step Mechanism That Determines the Donor Binding Specificity of Human UDP-N-acetylhexosaminyltransferase
Pub. Author: Mack Sobhany, and Masahiko Negishi
Pub. Year: 2005
Pub. Volume: 280
Pub. Pages: 23441–23445

PubMed ID: 15831490